PhD Scholarship Opportunity. Mathematical Biophysics. Single Molecule Fluorescence and Protein-Protein Binding

School of Mathematics and Statistics

Closing date: 21st July 2017

The project aims to elucidate the molecular mechanisms that drive the self-assembly of functionally distinct actin tropomyosin filaments using mathematical modelling and single-molecule biophysics. Data from surface chemistry, microfluidics and fluorescence microscopy will quantitate the interactions between tropomyosins and actin filaments at high temporal resolution. The project will determine binding kinetics, test models for cooperativity, assess competition between tropomyosin isoforms and test drugs disrupting the stability of the actin cytoskeleton. The outcome is the first quantitative and predictive model of the actin cytoskeleton. The work will reveal principles for co-assembly of specialised structures in the crowded cellular environment.

The project is suitable for students with the equivalent of a first-class honours in mathematics, physics, engineering or computer science. The investigation is a part of the collaboration between Adelle Coster and Till Böaut;cking in the Faculty of Medicine - more details here. The studies will be supervised by Adelle Coster, with co-supervision from Bruce Henry (Mathematics) and Peter Gunning (Medicine).

UNSW Scientia PhD scholars are awarded a prestigious scholarship package of $50,000 per annum, comprising a tax-free living allowance of $40,000 per annum for 4 years, tuition fees for the full 4 year period, and a support package of up to $10,000 per annum to provide financial support for career development activities.

Please contact me by 21 July 2017 if you are interested in the opportunity. You will also need to complete an online application at the Scientia Scholarship website. Women, minorities and indigenous candidates are encouraged to apply.

A number of other mathematical projects can also be found on the Scientia Scholarship website.

**Mention you saw it on the AustMS website**